Products for Research Use Only
RegisterLogin

Beta-TrCP Antibody / BTRC

CAT: 0800-F54622-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-F54622-0.4MLSize:0.4 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1:25, Immunohistochemistry (FFPE) : 1:25, Western blot: 1:500-1:2000
UniProt
Q9Y297
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 17-52 from the human protein was used as the immunogen for the Beta-TrCP antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IF, IHC-P, WB
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Beta-TrCP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Beta-TrCP antibody is available for research use only.
Storage Conditions
Aliquot the Beta-TrCP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Beta-TrCP antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, nuclear
Image Legend
Western blot testing of human 1) HepG2 and 2) HEK293 cell lysate with Beta-TrCP antibody. Predicted molecular weight ~69 kDa.
Product Datasheet
Loading...

Related Products

CatalogName
F55073-0.05MLChoriogonadotropin beta Antibody / HCG-beta
F55073-0.2MLChoriogonadotropin beta Antibody / HCG-beta
V9669-20UGLH beta Antibody / Luteinizing Hormone beta
V9669SAF-100UGLH beta Antibody / Luteinizing Hormone beta
V9669-100UGLH beta Antibody / Luteinizing Hormone beta
F51190-0.4MLInterferon beta Antibody
V3209SAF-100UGBeta Catenin Antibody
V7020-100UGHCG-beta Antibody
V7475-100UGBeta Catenin Antibody
V3708SAF-100UGHCG-beta Antibody

Alternative Products

CatalogName
A01747-1Anti-Beta TRCP/BTRC Antibody
GTR18044917-01β-TrCP/BTRC polyclonal antibody
BS80198β-TrCP/BTRC polyclonal antibody
E28PE4978BTRC (Beta TRCP) (1S10) Mouse Monoclonal antibody
E28PE4977BTRC (Beta TRCP) (18E8) Mouse Monoclonal antibody
E28PE4979BTRC (Beta TRCP) (14U13) Mouse Monoclonal antibody
E28PE4980BTRC (Beta TRCP) (2Z8) Mouse Monoclonal antibody
E45M10932V-2Beta TRCP (BTRC) Mouse Monoclonal Antibody [Clone 1F3]
E45M10931Beta TRCP (BTRC) Mouse Monoclonal Antibody [Clone:1D4]
E45M10929Beta TRCP (BTRC) Mouse Monoclonal Antibody [Clone:2H2]

Popular Products