Beta-TrCP Antibody / BTRC

Beta-TrCP Antibody / BTRC

• Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.
• CAS Number: 9007-83-4
• UniProt: Q9Y297
• Host: Rabbit
• Immunogen: A portion of amino acids 17-52 from the human protein was used as the immunogen for the Beta-TrCP antibody.
• Clonality: Polyclonal
• Isotype: Ig
• Applications: IF, IHC-P, WB
• Format: Purified
• Buffer: In 1X PBS, pH 7.4, with 0.09% sodium azide
• Reconstitution: Aliquot the Beta-TrCP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This Beta-TrCP antibody is available for research use only.