CBFB Antibody

CAT: 0800-F54434-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
CAT#:0800-F54434-0.08MLSize:0.08 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Core-binding factor subunit beta is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2) . The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters.
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:2000, Immunofluorescence: 1:25, Flow cytometry: 1:25 (1x10e6 cells), Immunohistochemistry (FFPE) : 1:25
UniProt
Q13951
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 61-90 from the human protein was used as the immunogen for the CBFB antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IF, FACS, IHC-P
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the CBFB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CBFB antibody is available for research use only.
Storage Conditions
Aliquot the CBFB antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the CBFB antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Nuclear
Image Legend
Western blot testing of 1) human K562 and 2) mouse lung lysate with CBFB antibody. Predicted molecular weight ~22 kDa.

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