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GFRAL Antibody

CAT: 0800-F54320-0.05MLSize: 0.05 mLDry Ice: NoHazardous: No
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CAT#:0800-F54320-0.05MLSize:0.05 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:25, Flow cytometry: 1:25 (1x10e6 cells)
UniProt
Q6UXV0
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 366-394 from the human protein was used as the immunogen for the GFRAL antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, FACS
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the GFRAL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This GFRAL antibody is available for research use only.
Storage Conditions
Aliquot the GFRAL antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the GFRAL antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of human brain lysate with GFRAL antibody. Predicted molecular weight ~45 kDa.

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