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HLA-DPB1 Antibody

CAT: 0800-F54283-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F54283-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:25, Flow cytometry: 1:25 (1x10e6 cells)
UniProt
P04440
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 77-105 from the human protein were used as the immunogen for the HLA-DPB1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P, FACS
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the HLA-DPB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This HLA-DPB1 antibody is available for research use only.
Storage Conditions
Aliquot the HLA-DPB1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the HLA-DPB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cell surface
Image Legend
IHC testing of FFPE human tonsil tissue with HLA-DPB1 antibody.

UniProtKB · P04440

HLA class II histocompatibility antigen, DP beta 1 chain

DPB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04440
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HLA-DPB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0PFJ7, A5I886, A8YPB3, B5U8B4, B7VF80, B7VF87, B8ZX68, B8ZYT0, B9W5S8, B9W6F7, B9W6F9, C0MPP5, C0MPQ2, C0MPQ3, C0MPQ5, C0MPQ6, C0MPQ7, C4R9J5, C5IZL1, O00259, O19698, O19700, O19702, O19749, O46884, O77952, O98215, O98216, O98217, O98218, O98219, O98222, O98223, P01916, P04232, P13763, P79493, P79608, Q0P0L4, Q0ZFN3, Q14279, Q27S71, Q29682, Q29684, Q29698, Q29714, Q29775, Q29776, Q29778, Q29779, Q29781, Q29827, Q29828, Q29879, Q29880, Q29898, Q29977, Q2MGW3, Q30015, Q30031, Q30032, Q30033, Q30034, Q30050, Q30051, Q30052, Q30053, Q30054, Q30055, Q30174, Q4GY31, Q4JHD8, Q5ENE0, Q5ENE1, Q5ENW3, Q5EP46, Q5EP47, Q5EP49, Q5EP51, Q5EP52, Q5EP53, Q5EP56, Q5I4H8, Q5I4H9, Q5ISH4, Q5ISH5, Q5SQ73, Q5STP2, Q5YLA6, Q6IVX1, Q6LBX2, Q6LBX3, Q6LBX4, Q6LBX5, Q6LBX6, Q6LBX7, Q6PWX6, Q6TAS4, Q714U1, Q714U2, Q7YQ10, Q860Z7, Q8HWL7, Q8HWT5, Q8SNC4, Q95HC1, Q95IT7, Q95IT8, Q9BD13, Q9GIM2, Q9GIM4, Q9GIX6, Q9GJ41, Q9MY67, Q9TNT7, Q9TQE2, Q9XS11, Q9XS12
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityImmunity

Cellular component

Cell membraneEndoplasmic reticulumEndosomeGolgi apparatusLysosomeMembraneMHC II

PTM

Disulfide bondGlycoprotein

Domain

SignalTransmembraneTransmembrane helix

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