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FADD Antibody

CAT: 0800-F54022-0.1MLSize: 0.1 mLDry Ice: NoHazardous: No
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CAT#:0800-F54022-0.1MLSize:0.1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:500, Immunoprecipitation: suitable
UniProt
Q13158
Host
Mouse
Reactivity
Human
Immunogen
A human recombinant protein was used as the immunogen for this FADD antibody.
Clonality
Monoclonal
Isotype
IgG2a
Clone
5A3-C7-G9
Applications
WB, IP
Purity
Protein G affinity
Format
Purified
Buffer
Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Reconstitution
Store the FADD antibody at -20oC.
Limitations
This FADD antibody is available for research use only.
Storage Conditions
Store the FADD antibody at -20°C.
Formulation
In PBS with 50% glycerol and 0.03% ProClin 300
Applications Notes
The stated application concentrations are suggested starting points. Titration of the FADD antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Immunoprecipitation of FADD from HeLa cell lysate using FADD antibody. The precipitate was subsequently immunoblotted with the same mAb.

UniProtKB · Q13158

FAS-associated death domain protein

FADD_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13158
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FADD
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q14866, Q6IBR4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

ApoptosisHost-virus interactionImmunityInnate immunity

Cellular component

Cytoplasm

Disease

Disease variant

PTM

GlycoproteinPhosphoprotein

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