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MEK1/2 Antibody

CAT: 0800-F54006-0.1MLSize: 0.1 mLDry Ice: NoHazardous: No
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CAT#:0800-F54006-0.1MLSize:0.1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:500
UniProt
P36507, Q02750
Host
Mouse
Reactivity
Human
Immunogen
A human recombinant MEK1 protein was used as the immunogen for this MEK1/2 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
6F10-D7-G6
Applications
WB
Purity
Protein G affinity
Format
Purified
Buffer
Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Reconstitution
Store the MEK1/2 antibody at -20oC.
Limitations
This MEK1/2 antibody is available for research use only.
Storage Conditions
Store the MEK1/2 antibody at -20°C.
Formulation
In PBS with 50% glycerol and 0.03% ProClin 300
Applications Notes
The stated application concentrations are suggested starting points. Titration of the MEK1/2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot detection of MEK1/2 in human A549, MCF7 and HeLa cell lysates using MEK1/2 antibody at 1:500. Predicted molecular weight: 43/44 kDa.

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