RegisterLogin

ECT2 Antibody

CAT: 0800-F53947-0.05MLSize: 0.05 mLDry Ice: NoHazardous: No
CAT#:0800-F53947-0.05MLSize:0.05 mL
Selected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Epithelial cell-transforming sequence 2 oncogene is a guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role in the control of mitotic spindle assembly; regulates the activation of CDC42 in metaphase for the process of spindle fibers attachment to kinetochores before chromosome congression. Involved in the regulation of epithelial cell polarity; participates in the formation of epithelial tight junctions in a polarity complex PARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role in the regulation of neurite outgrowth. Inhibits phenobarbital (PB) - induced NR1I3 nuclear translocation. Stimulates the activity of RAC1 through its association with the oncogenic PARD6A-PRKCI complex in cancer cells, thereby acting to coordinately drive tumor cell proliferation and invasion. Also stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1000
UniProt
Q9H8V3
Host
Mouse
Reactivity
Human
Immunogen
A partial recombinant protein corresponding to amino acids 200-460 from the human protein was used as the immunogen for the ECT2 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1691CT516.3.3
Applications
WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ECT2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ECT2 antibody is available for research use only.
Storage Conditions
Aliquot the ECT2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the ECT2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of human 293T/17 cell lysate with ECT2 antibody at 1:1000. Predicted molecular weight: 104 kDa.

Related Products

CatalogName
RQ4624NONO Antibody / p54nrb Antibody
F53954-0.05MLAntibody
F53954-0.2MLAntibody
F53952-0.05MLAntibody
F53952-0.2MLAntibody
V8674-20UGInhibin alpha Antibody / INHA antibody
V8674-100UGInhibin alpha Antibody / INHA antibody
V8674SAF-100UGInhibin alpha Antibody / INHA antibody
R20161SAF-250UGLambda Light Chain Antibody / Lambda Antibody
R20179SAF-250UGLambda Light Chain Antibody / Lambda Antibody

Alternative Products

CatalogName
abx457127-01Protein ECT2 (ECT2) Antibody
E45M02569G-4ECT2 Antibody
43917ECT2 Antibody
GWB-MS591FECT2 Antibody
OACD03155-100ULECT2 Antibody
OACD03154-100ULECT2 Antibody
OACD03154-1MLECT2 Antibody
CSB-PA888001LA01HU-01ECT2 Antibody
MBS9630936-01ECT2 Antibody
MBS9217316-01ECT2 Antibody

Popular Products