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NANOG Antibody

CAT: 0800-F53329-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F53329-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'- [CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000-2000
UniProt
Q9H9S0
Host
Rabbit
Reactivity
Human
Immunogen
This NANOG antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 155-189 amino acids from the Central region of human NANOG.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the NANOG antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This NANOG antibody is available for research use only.
Storage Conditions
Aliquot the NANOG antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the NANOG antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of NANOG antibody at 1:2000 dilution + human brain lysate; Predicted molecular weight: 35-45 kDa.

UniProtKB · Q9H9S0

Homeobox protein NANOG

NANOG_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9H9S0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NANOG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
D3DUU4, Q2TTG0, Q6JZS5
Protein keywords

Technical term

3D-structureReference proteome

Molecular function

ActivatorDevelopmental proteinDNA-bindingRepressor

Coding sequence diversity

Alternative splicing

Domain

HomeoboxRepeat

Cellular component

Nucleus

Biological process

TranscriptionTranscription regulation

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