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FGFR1 Antibody

CAT: 0800-F53032-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F53032-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
CAS Number
9007-83-4
Specifications
Western blot: 1:2000, Immunofluorescence: 1:25, Immunohistochemistry (FFPE) : 1:25
UniProt
P11362
Host
Mouse
Reactivity
Human
Immunogen
This FGFR1 antibody was produced from a mouse immunized with a KLH conjugated synthetic peptide between 806-842 amino acids from the C-terminal region of human FGFR1.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1440CT772.50.23
Applications
WB, IF, IHC-P, ELISA (immunogen)
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the FGFR1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This FGFR1 antibody is available for research use only.
Storage Conditions
Aliquot the FGFR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the FGFR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of lysate from HeLa cell line using FGFR1 antibody at 1:2000. Predicted molecular weight: 75-160 kDa depending on glycosylation level.
Product Datasheet
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