P62 Antibody

• Description:

  Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) . Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity) . May be involved in cell differentiation, apoptosis, immune response and regulation of K (+) channels.

• Specifications:

  Western blot: 1:1000

• UniProt:

  Q13501

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  This p62 antibody was produced from mice immunized with a recombinant protein.

• Clonality:

  Monoclonal

• Isotype:

  IgG1 k

• Clone:

  1336CT763.152.125

• Applications:

  WB, ELISA

• Purity:

  Purified

• Format:

  Purified

• Buffer:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Reconstitution:

  Aliquot the p62 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This p62 antibody is available for research use only.

• Storage Conditions:

  Aliquot the p62 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes:

  Titration of the p62 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• CAS Number:

  9007-83-4

• Image Legend:

  Western blot analysis of lysate from A549 cell line using p62 antibody at 1:1000. Observed molecular weight ~62 kDa.