Egfr Antibody

CAT: 0800-F52880-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
CAT#:0800-F52880-0.4MLSize:0.4 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q01279
Host
Rabbit
Reactivity
Mouse
Immunogen
This mouse Egfr antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1116-1130 amino acids from the human region of mouse Egfr.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Egfr antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Egfr antibody is available for research use only.
Storage Conditions
Aliquot the Egfr antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Egfr antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, membranous
Image Legend
Western blot analysis of lysate from mouse liver tissue using Egfr antibody diluted at 1:1000. Expected molecular weight: ~134/170 kDa (unmodified/glycosylated) .

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