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Nucleophosmin Antibody

CAT: 0800-F52273-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F52273-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nucleophosmin is involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication.
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:25, Western blot: 1:1000
UniProt
P06748
Host
Mouse
Reactivity
Human
Immunogen
Purified His-tagged protein was used to produced this monoclonal Nucleophosmin antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
1042CT5.2.1
Applications
IHC, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Nucleophosmin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Nucleophosmin antibody is available for research use only.
Storage Conditions
Aliquot the Nucleophosmin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Nucleophosmin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Immunohistochemical analysis of paraffin-embedded human thymus using Nucleophosmin antibody at 1:25 dilution.

UniProtKB · P06748

Nucleophosmin

NPM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P06748
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NPM1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
NPM
EC number
—
Processing
—
Secondary accessions
A8K3N7, B5BU00, D3DQL6, P08693, Q12826, Q13440, Q13441, Q14115, Q5EU94, Q5EU95, Q5EU96, Q5EU97, Q5EU98, Q5EU99, Q6V962, Q8WTW5, Q96AT6, Q96DC4, Q96EA5, Q9BYG9, Q9UDJ7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationADP-ribosylationDisulfide bondIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Molecular function

ChaperoneRNA-binding

Cellular component

CytoplasmCytoskeletonNucleus

Biological process

Host-virus interaction

Disease

Proto-oncogene

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