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Cyclin D2 Antibody (CCND2)

CAT: 0800-F52196-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F52196-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G (1) /S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase. Hypophosphorylates RB1 in early G (1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity) .
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P30279
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 258-285 from the human protein was used as the immunogen for this Cyclin D2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Cyclin D2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Cyclin D2 antibody is available for research use only.
Storage Conditions
Aliquot the Cyclin D2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Cyclin D2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Bovine, Pig
Image Legend
Cyclin D2 antibody western blot analysis in MDA-MB231 lysate. Predicted molecular weight ~33 kDa.

UniProtKB · P30279

G1/S-specific cyclin-D2

CCND2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P30279
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCND2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K531, Q13955, Q5U035
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell cycleCell division

Molecular function

Cyclin

Cellular component

CytoplasmMembraneNucleus

Disease

Disease variant

PTM

PhosphoproteinUbl conjugation
Product Datasheet
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