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Urokinase Antibody

CAT: 0800-F51093-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F51093-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PLAU, a member of the peptidase family S1, is a potent plasminogen activator and is clinically used for therapy of thrombolytic disorders. PLAU specifically cleaves the Arg-|-Val bond in plasminogen to form plasmin. The protein is found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A. Cleavage occurs after residue 155 in the low molecular mass form to yield a short A1 chain. The protein is used in Pulmonary Embolism (PE) to initiates fibrinolysis. Structurally, PLAU contains 1 EGF-like domain and 1 kringle domain.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50, Flow Cytometry: 1:10-1:50
UniProt
P00749
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 60-90 from the human protein was used as the immunogen for this Urokinase antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, FACS, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Urokinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Urokinase antibody is available for research use only.
Storage Conditions
Aliquot the Urokinase antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Urokinase antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of Urokinase antibody and A2058 lysate

UniProtKB · P00749

Urokinase-type plasminogen activator

UROK_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P00749
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PLAU
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
U-plasminogen activator, Urokinase, uPA
EC number
3.4.21.73
Processing
Precursor
Secondary accessions
B4DPZ2, Q15844, Q16618, Q53XS3, Q5SWW9, Q969W6
Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Blood coagulationFibrinolysisHemostasisPlasminogen activation

PTM

Disulfide bondGlycoproteinPhosphoproteinZymogen

Domain

EGF-like domainKringleSignal

Molecular function

HydrolaseProteaseSerine protease

Cellular component

Secreted

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