PERK Antibody

PERK Antibody

• Description: PERK, a member of the GCN2 subfamily of Ser/Thr protein kinases, phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It likely serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1 Perturbation in protein folding in the endoplasmic reticulum (ER) promotes reversible dissociation from HSPA5/BIP and oligomerization, resulting in transautophosphorylation and kinase activity induction Expression of this Type I membrane protein is ubiquitous, with highest levels seen in secretory tissues. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.
• CAS Number: 9007-83-4
• UniProt: Q9NZJ5
• Host: Rabbit
• Immunogen: A portion of amino acids 148-175 from the human protein was used as the immunogen for this PERK antibody.
• Clonality: Polyclonal
• Isotype: Ig
• Applications: WB, IHC, ELISA
• Format: Purified
• Buffer: In 1X PBS pH 7.4 with 0.09% sodium azide
• Reconstitution: Aliquot the PERK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This PERK antibody is available for research use only.