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Eph Receptor B2 Antibody [EphB2]

CAT: 0800-F50585-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F50585-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ligand-activated form of EphB2, which belongs to the Tyr family of protein kinases, interacts with multiple proteins, including GTPase-activating protein (RASGAP) through its SH2 domain. It binds RASGAP through the juxtamembrane tyrosines residues, and also interacts with PRKCABP and GRIP1 This type I membrane protein is expressed in brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. It is preferentially expressed in fetal brain. This protein contains putatively 2 fibronectin type III domains and 1 sterile alpha motif (SAM) domain.
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:10-1:100
UniProt
P29323
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 103-133 from the human protein was used as the immunogen for this EphB2 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the EphB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This EphB2 antibody is available for research use only.
Storage Conditions
Aliquot the EphB2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the EphB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
EphB2 antibody analysis in formalin fixed and paraffin embedded human skeletal muscle

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