RegisterLogin

SPHK2 Antibody

CAT: 0800-F50220-0.2MLSize: 0.2 mLDry Ice: NoHazardous: No
CAT#:0800-F50220-0.2MLSize:0.2 mL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P) . S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
Q9NRA0
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 590-620 from the human protein was used as the immunogen for this SPHK2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the SPHK2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This SPHK2 antibody is available for research use only.
Storage Conditions
Aliquot the SPHK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the SPHK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
SPHK2 antibody western blot analysis in HepG2 lysate. Predicted molecular weight ~69 kDa.
Product Datasheet
Loading...

Related Products

CatalogName
F50216-0.4MLSPHK1 Antibody
F50218-0.4MLSPHK1 Antibody
R33664-100UGSPHK1 Antibody
F50218-0.08MLSPHK1 Antibody
F40149-0.4MLSPHK1 Antibody
F40149-0.08MLSPHK1 Antibody
F50216-0.08MLSPHK1 Antibody
F50217-0.05MLSPHK1 Antibody
F50217-0.2MLSPHK1 Antibody
RQ7823Sphingosine kinase 1 Antibody / SPHK1

Alternative Products

CatalogName
MBS7125051-01SPHK2 Antibody

Popular Products