GRB2 Antibody

CAT: 0800-F49558-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
CAT#:0800-F49558-0.4MLSize:0.4 mL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
GRB2 is an adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
P62993
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 89-118 from the human protein was used as the immunogen for this GRB2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Store at 4oC for up to one month. For long term, aliquot the GRB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This GRB2 antibody is available for research use only.
Storage Conditions
Store at 4°C for up to one month. For long term, aliquot the GRB2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the GRB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse, Rat, Xenopus
Image Legend
Western blot analysis of GRB2 antibody and 293 cell lysate (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GRB2 gene (2) . Predicted molecular weight ~25kDa.

Related Products

CatalogName
FY12491GAREM1 Antibody / GRB2-associated and regulator of MAPK protein 1
RQ7278Growth factor receptor bound protein 2 Antibody / GRB2
R30667GRB7 Antibody
R33858-100UGGRB7 Antibody
RQ5729GRB7 Antibody / Growth factor receptor-bound protein 7
RQ4624NONO Antibody / p54nrb Antibody
F53954-0.05MLAntibody
F53954-0.2MLAntibody
F53952-0.05MLAntibody
F53952-0.2MLAntibody

Alternative Products

CatalogName
MBS7123748-01GRB2 Antibody

Popular Products