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NRG1 Antibody

CAT: 0800-F49507-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F49507-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF) . They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Flow Cytometry: 1:10-1:50, IHC (Paraffin) : 1:50-1:100
UniProt
Q02297
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 198-229 from the human protein was used as the immunogen for this NRG1 antibody. The amino acid sequence used as immunogen is 100% homologous in isoforms Alpha, Alpha1A, Alpha2B, Alpha2 and Alpha3. It is not suitable for detecting the Beta isoforms or the GGF2 isoform.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the NRG1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This NRG1 antibody is available for research use only.
Storage Conditions
Aliquot the NRG1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the NRG1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, membranous, secreted
Image Legend
Western blot analysis of NRG1 antibody and SK-BR-3 lysate. Predicted molecular weight of multiple isofoms: 26-70 kDa.
Product Datasheet
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