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CD63 Antibody / LAMP-3

CAT: 0800-F49127-0.05MLSize: 0.05 mLDry Ice: NoHazardous: No
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CAT#:0800-F49127-0.05MLSize:0.05 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD63 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. The use of alternate polyadenylation sites has been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (FFPE) : 1:25, FACS: 1:25 per 1x10^6 cells
UniProt
P08962
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 163-190 from the human protein was used as the immunogen for this CD63 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the CD63 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CD63 antibody is available for research use only.
Storage Conditions
Aliquot the CD63 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the CD63 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasm, cell surface and secreted
Image Legend
Western blot testing of CD63 antibody at 1:2000 dilution. Lane 1: A2058 lysate; 2: A375 lysate; 3: THP-1 lysate; 4: U-87 MG lysate; Predicted molecular weight: 25-60 kDa depending on glycosylation level.

UniProtKB · P08962

CD63 antigen

CD63_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08962
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD63
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
F8VZE2, Q5TZP3, Q8N6Z9, Q9UCG6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneEndosomeLysosomeMembraneSecreted

PTM

GlycoproteinLipoproteinPalmitate

Biological process

Protein transportTransport

Domain

TransmembraneTransmembrane helix

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