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Phospho-Kit Antibody (pY936)

CAT: 0800-F48724-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F48724-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor) . Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Dot blot: 1:500
UniProt
P10721
Host
Rabbit
Reactivity
Human
Immunogen
This phospho-Kit antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY936 of human c-Kit.
Clonality
Polyclonal
Isotype
Ig
Applications
DB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the phospho-Kit antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This phospho-Kit antibody is available for research use only.
Storage Conditions
Aliquot the phospho-Kit antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the phospho-Kit antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Bovine, Pig
Image Legend
Dot blot analysis of phospho-Kit antibody. 50ng of phos-peptide or nonphos-peptide per dot were spotted.

UniProtKB · P10721

Mast/stem cell growth factor receptor Kit

KIT_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P10721
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KIT
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SCFR
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
B5A956, D5LXN2, D5M931, F5H8F8, Q6IQ28, Q99662, Q9UM99
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmMembrane

Disease

Disease variantProto-oncogene

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Molecular function

KinaseReceptorTransferaseTyrosine-protein kinase

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