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MAP2 Antibody (phospho-S1539)

CAT: 0800-F48609-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F48609-0.08MLSize:0.08 mL
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Description
MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2; two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20, MAP2a appears. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton.
CAS Number
9007-83-4
UniProt
P11137
Host
Rabbit
Immunogen
This phospho-MAP2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS1539 of human MAP2.
Clonality
Polyclonal
Isotype
Ig
Applications
DB, ELISA
Format
Antigen affinity purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the phospho-MAP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This phospho-MAP2 antibody is available for research use only.

UniProtKB · P11137

Microtubule-associated protein 2

MTAP2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P11137
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAP2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MAP-2
EC number
—
Processing
—
Secondary accessions
Q17S04, Q8IUX2, Q99975, Q99976
Protein keywords

Coding sequence diversity

Alternative splicing

Molecular function

Calmodulin-binding

Cellular component

Cell projectionCytoplasmCytoskeletonMicrotubule

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Domain

Repeat
Product Datasheet
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