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P70S6K Antibody

CAT: 0800-F48468-0.2MLSize: 0.2 mLDry Ice: NoHazardous: No
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CAT#:0800-F48468-0.2MLSize:0.2 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RPS6kB1 is a serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50
UniProt
P23443
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 425-454 from human RPS6KB1 was used as the immunogen for this p70S6K antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the p70S6K antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This p70S6K antibody is available for research use only.
Storage Conditions
Aliquot the p70S6K antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the p70S6K antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Bovine, Mouse, Rabbit, Rat
Image Legend
Western blot analysis of p70S6K antibody and TNF alpha activated HeLa lysate; both phospho and non-phos S6K can be detected with this Ab. Predicted molecular weight: 60-70 kDa

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