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TFEB Antibody

CAT: 0800-F46977-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
CAT#:0800-F46977-0.08MLSize:0.08 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5') . Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4 (+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P19484
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 271-300 from the human protein was used as the immunogen for this TFEB antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the TFEB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TFEB antibody is available for research use only.
Storage Conditions
Aliquot the TFEB antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the TFEB antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse
Image Legend
TFEB antibody western blot analysis in HepG2 lysate. Expected molecular weight: 53-60 kDa (unmodified), 65-70 kDa (modified) .

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MBS8513851-01TFEB Antibody

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