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OSCAR Antibody

CAT: 0800-F46863-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F46863-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q8IYS5
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 205-231 from the human protein was used as the immunogen for this OSCAR antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the OSCAR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This OSCAR antibody is available for research use only.
Storage Conditions
Aliquot the OSCAR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the OSCAR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
OSCAR antibody western blot analysis in 293 lysate.

UniProtKB · Q8IYS5

Osteoclast-associated immunoglobulin-like receptor

OSCAR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8IYS5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
OSCAR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Osteoclast-associated receptor, hOSCAR
EC number
—
Processing
Precursor
Secondary accessions
B7WNS2, Q5GRG5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoprotein

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Molecular function

Receptor

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