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GPNMB Antibody

CAT: 0800-F45454-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F45454-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q14956
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 541-569 from the human protein was used as the immunogen for this GPNMB antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the GPNMB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This GPNMB antibody is available for research use only.
Storage Conditions
Aliquot the GPNMB antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the GPNMB antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
GPNMB antibody western blot analysis in CEM lysate.

UniProtKB · Q14956

Transmembrane glycoprotein NMB

GPNMB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14956
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GPNMB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A4D155, Q6UVX1, Q8N1A1
Protein keywords

Coding sequence diversity

Alternative splicing

Disease

AmyloidosisDisease variant

Cellular component

Cell membraneEndosomeMembrane

PTM

GlycoproteinPhosphoprotein

Technical term

Proteomics identificationReference proteome

Domain

SignalTransmembraneTransmembrane helix

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