Leptin Antibody

• Description:

  This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq].

• Specifications:

  Western blot: 1:1000, Immunofluorescence: 1:10-1:50, Immunohistochemistry (Paraffin) : 1:10-1:50, Flow cytometry: 1:10-1:50

• UniProt:

  P41159

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A portion of amino acids 8-37 from the human protein was used as the immunogen for this LEP antibody.

• Clonality:

  Polyclonal

• Isotype:

  Ig

• Applications:

  WB, IF, IHC, FACS, ELISA

• Purity:

  Antigen affinity

• Format:

  Antigen affinity purified

• Buffer:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Reconstitution:

  Aliquot the LEP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This LEP antibody is available for research use only.

• Storage Conditions:

  Aliquot the LEP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes:

  Titration of the LEP antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• Prediction Reactivity:

  Mouse

• CAS Number:

  9007-83-4

• Image Legend:

  LEP antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue.