CPT1C Antibody

CAT: 0800-F44576-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
CAT#:0800-F44576-0.4MLSize:0.4 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q8TCG5
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 596-625 from the human protein was used as the immunogen for this CPT1C antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the CPT1C antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CPT1C antibody is available for research use only.
Storage Conditions
Aliquot the CPT1C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the CPT1C antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
CPT1C antibody western blot analysis in HL-60 lysate. Predicted molecular weight 81-91 kDa.

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