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VDR Antibody

CAT: 0800-F44169-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F44169-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, Flow Cytometry: 1:10-1:50
UniProt
P11473
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 274-299 from the human protein was used as the immunogen for this VDR antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
FACS, WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the VDR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This VDR antibody is available for research use only.
Storage Conditions
Aliquot the VDR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the VDR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of lysate from 1) PC3, and 2) LNCaP cell line using VDR antibody at 1:1000. Predicted molecular weight 48/54 kDa (isoforms 1/2) .

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