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Cyclin D2 Antibody (CCND2)

CAT: 0800-F43829-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F43829-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P30279
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 1-30 from the human protein was used as the immunogen for this Cyclin D2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Cyclin D2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Cyclin D2 antibody is available for research use only.
Storage Conditions
Aliquot the Cyclin D2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Cyclin D2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Cyclin D2 antibody western blot analysis in CEM lysate. Predicted molecular weight ~33 kDa.

UniProtKB · P30279

G1/S-specific cyclin-D2

CCND2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P30279
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCND2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K531, Q13955, Q5U035
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell cycleCell division

Molecular function

Cyclin

Cellular component

CytoplasmMembraneNucleus

Disease

Disease variant

PTM

PhosphoproteinUbl conjugation

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