PITX2 Antibody

CAT: 0800-F43713-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
CAT#:0800-F43713-0.4MLSize:0.4 mL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1:10-1:50, Western blot: 1:1000
UniProt
Q99697
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 122-151 from the human protein was used as the immunogen for this PITX2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IF, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the PITX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PITX2 antibody is available for research use only.
Storage Conditions
Aliquot the PITX2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the PITX2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse, Rat, Chicken, Zebrafish, Xenopus
Image Legend
Fluorescent image of HeLa cell stained with PITX2 antibody. Alexa Fluor 488 conjugated secondary (green) was used. Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin. PITX2 immunoreactivity is localized to the nucleus.
Product Datasheet
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