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AR Antibody

CAT: 0800-F42684-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F42684-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease) . Mutations in this gene are also associated with complete androgen insensitivity (CAIS) . Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq].
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P10275
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 282-309 from the human protein was used as the immunogen for this AR antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the AR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This AR antibody is available for research use only.
Storage Conditions
Aliquot the AR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the AR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Primate
Image Legend
AR antibody western blot analysis in (1) NCI-H292, and (1) NCI-H460 lysate. Predicted molecular weight ~99kDa.

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