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XBP1 Antibody

CAT: 0800-F42468-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F42468-0.4MLSize:0.4 mL
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Description
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1) . The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1 (S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1 (U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1 (S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P17861
Host
Rabbit
Reactivity
Mouse
Immunogen
A portion of amino acids 217-244 from the human protein was used as the immunogen for this XBP1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the XBP1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This XBP1 antibody is available for research use only.
Storage Conditions
Aliquot the XBP1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the XBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
XBP1 antibody western blot analysis in mouse lung tissue lysate. Predicted molecular weight: ~29 kDa (isoform 1) and ~40 kDa (isoform 2) .

UniProtKB · P17861

X-box-binding protein 1

XBP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17861
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
XBP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
XBP-1
EC number
—
Processing
—
Secondary accessions
Q8WYK6, Q969P1, Q96BD7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationCleavage on pair of basic residuesPhosphoproteinUbl conjugation

Molecular function

ActivatorDevelopmental proteinDNA-binding

Coding sequence diversity

Alternative splicing

Biological process

AngiogenesisApoptosisAutophagyDifferentiationLipid biosynthesisLipid metabolismMyogenesisProtein transportStress responseTranscriptionTranscription regulationTransportUnfolded protein response

Cellular component

CytoplasmEndoplasmic reticulumMembraneNucleus

Disease

Oncogene

Domain

Signal-anchorTransmembraneTransmembrane helix

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AF6712-01XBP1 Antibody

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