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GSK5750

CAT: 0804-HY-116454Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116454Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK5750 is a specific and potent HIV-1 reverse transcriptase ribonuclease H inhibitor with an IC50 value of 0.33 μM. GSK5750 is bound at the RNase H active site through a metalion chelation mechanism[1].
CAS Number
1312345-89-3
UNSPSC
12352005
Target
HIV; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gsk5750.html
Smiles
O=C1N(O)C2=NC=CC=C2C(NCC3=CC4=CC=CC=C4S3)=N1
Molecular Formula
C16H12N4O2S
Molecular Weight
324.36
References & Citations
[1]Beilhartz GL, et al. Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation. J Biol Chem. 2014 Jun 6;289 (23) :16270-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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