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IL-12B Antibody

CAT: 0800-F40666-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F40666-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL12B is a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:50-1:100, Flow Cytometry: 1:10-1:50, Western blot: 1:1000
UniProt
P29460
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 264-290 from the human protein was used as the immunogen for this IL-12B antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, FACS, WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the IL-12B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This IL-12B antibody is available for research use only.
Storage Conditions
Aliquot the IL-12B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the IL-12B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
IL-12B antibody flow cytometric analysis of MDA-MB435 cells (green) compared to a negative control (blue) . FITC-conjugated goat-anti-rabbit secondary Ab was used for the analysis.
Product Datasheet
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