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STIM1 Antibody

CAT: 0800-F40480-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F40480-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs) . It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
Q13586
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 509-538 from the human protein was used as the immunogen for this STIM1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the STIM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This STIM1 antibody is available for research use only.
Storage Conditions
Aliquot the STIM1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the STIM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse
Image Legend
STIM1 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue.

UniProtKB · Q13586

Stromal interaction molecule 1

STIM1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13586
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
STIM1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
E9PQJ4, Q8N382
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Biological process

Calcium transportIon transportTransport

Cellular component

Cell membraneCytoplasmCytoskeletonEndoplasmic reticulumMembraneMicrotubuleSarcoplasmic reticulum

Domain

Coiled coilSignalTransmembraneTransmembrane helix

Disease

Disease variant

PTM

GlycoproteinPhosphoprotein
Product Datasheet
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