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PARK8 Antibody

CAT: 0800-F40408-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F40408-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
CAS Number
9007-83-4
Specifications
Western blot: 1:100-1:500
UniProt
Q5S007
Host
Mouse
Reactivity
Human, Mouse
Immunogen
This PARK8 antibody was raised in mice using purified His-tagged recombinant protein comprised of the C-terminal 261 residues of LRRK2.
Clonality
Monoclonal
Isotype
IgG1
Clone
133AT1218
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the PARK8 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PARK8 antibody is available for research use only.
Storage Conditions
Aliquot the PARK8 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the PARK8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
The PARK8 antibody used in western blot to detect LRRK2/PARK8 in mouse brain cell lysate

UniProtKB · Q5S007

Leucine-rich repeat serine/threonine-protein kinase 2

LRRK2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q5S007
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LRRK2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1, 3.6.5.-
Processing
—
Secondary accessions
A6NJU2, Q6ZS50, Q8NCX9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

ATP-bindingGTP-bindingNucleotide-binding

Biological process

AutophagyDifferentiation

Cellular component

Cell projectionCytoplasmCytoplasmic vesicleCytoskeletonEndoplasmic reticulumEndosomeGolgi apparatusLysosomeMembraneMitochondrionMitochondrion outer membraneSynapse

Domain

Coiled coilLeucine-rich repeatRepeatWD repeat

Disease

Disease variantNeurodegenerationParkinson diseaseParkinsonism

Molecular function

GTPase activationHydrolaseKinaseSerine/threonine-protein kinaseTransferase

PTM

PhosphoproteinUbl conjugation
Product Datasheet
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