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EGF Receptor Antibody

CAT: 0800-F40405-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F40405-0.08MLSize:0.08 mL
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Description
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
CAS Number
9007-83-4
UniProt
P00533
Host
Mouse
Immunogen
A portion of amino acids 1163-1191 from the human protein was used as the immunogen for this EGF Receptor antibody.
Clonality
Monoclonal
Isotype
IgG1
Applications
WB, IHC, ELISA
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the EGF Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This EGF Receptor antibody is available for research use only.

UniProtKB · P00533

Epidermal growth factor receptor

EGFR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P00533
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EGFR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
O00688, O00732, P06268, Q14225, Q68GS5, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneEndoplasmic reticulumEndosomeGolgi apparatusMembraneNucleusSecreted

Molecular function

Developmental proteinHost cell receptor for virus entryKinaseReceptorTransferaseTyrosine-protein kinase

Disease

Disease variantProto-oncogene

PTM

Disulfide bondGlycoproteinHydroxylationIsopeptide bondLipoproteinMethylationPalmitatePhosphoproteinUbl conjugation

Biological process

Host-virus interaction

Domain

RepeatSignalTransmembraneTransmembrane helix
Product Datasheet
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