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UchL1 Antibody

CAT: 0800-F40308-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F40308-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:25, Immunofluorescence: 1:25, Western blot: 1:120-1:1000
UniProt
P09936
Host
Mouse
Reactivity
Human
Immunogen
This UchL1 antibody was produced from a mouse immunized with UchL1 recombinant protein.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
346CT2.2.1
Applications
IHC, IF, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the UCHL1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This UchL1 antibody is available for research use only.
Storage Conditions
Aliquot the UchL1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the UchL1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of lysate from 1) NCI-H460, 2) U266, 3) mouse Neuro-2a, rat 4) PC-12 and 5) C6 cell line and 6) mouse brain tissue using UchL1 antibody at 1:1000. Predicted molecular weight ~25 kDa.

UniProtKB · P09936

Ubiquitin carboxyl-terminal hydrolase isozyme L1

UCHL1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09936
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
UCHL1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
UCH-L1
EC number
3.4.19.12
Processing
Precursor
Secondary accessions
Q4W5K6, Q71UM0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycoproteinLipoproteinOxidationPhosphoproteinPrenylation

Coding sequence diversity

Alternative initiation

Cellular component

CytoplasmEndoplasmic reticulumMembrane

Disease

Disease variantHereditary spastic paraplegiaNeurodegenerationParkinson diseaseParkinsonism

Molecular function

HydrolaseProteaseThiol protease

Biological process

Ubl conjugation pathway

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