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PKR Antibody

CAT: 0800-F40174-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
CAT#:0800-F40174-0.4MLSize:0.4 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interferon-induced, double-stranded RNA-activated protein kinase (PRKR/PKR) is a serine-threonine kinase. Activation by dsRNAs leads to autophosphorylation of PKR and allows the kinase to phosphorylate its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor-2 (EIF2-alpha), leading to the inhibition of protein synthesis. PRKR, which is involved in TLR signaling and mediates apoptosis in fibroblasts in response to viral infection and inflammatory cytokines, activates IKK and NFKB, thereby suppressing apoptosis. Apoptosis induced by live pathogenic gram-positive and gram-negative bacteria requirs both TLR4 and PKR, possibly representing a major mechanism for pathogenic bacteria that use specific virulence factors to avoid detection and destruction by the innate immune system.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
P19525
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 11-42 from the human protein was used as the immunogen for this PKR antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the PKR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PKR antibody is available for research use only.
Storage Conditions
Aliquot the PKR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the PKR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
PKR antibody used in western blot to detect PRKR/PKR in mouse liver tissue lysate (Lane 1) and HepG2 cell lysate (2) . Predicted molecular weight ~62 kDa but routinely observed at 68-72 kDa.
Product Datasheet
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