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ILK2/ILK1 Antibody

CAT: 0800-F40141-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F40141-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK) is an ankyrin repeat containing 51 kDa receptor-proximate serine-threonine kinase (1), with a reported migration rate of 59K. This 451 amino acid protein interacts with the cytoplasmic domain of the beta-1 integrin subunit and contains sequence motifs found in pleckstrin homology domains capable of interacting with phosphoinositide lipids. ILK is an upstream regulator of Pi (3) K dependant activation of protein kinase B (PKB/AKT) and inhibition of glycogen synthase kinase 3 (GSK-3) . ILK2 expression is associated with mediation of cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. ILK2 is overexpressed in some highly invasive tumor cell lines.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q13418
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 391-421 from the human protein was used as the immunogen for this ILK2/ILK1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ILK2/ILK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ILK2/ILK1 antibody is available for research use only.
Storage Conditions
Aliquot the ILK2/ILK1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the ILK2/ILK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Rat, Bovine
Image Legend
Western blot analysis of ILK2/ILK1 antibody and HeLa lysate.

UniProtKB · Q13418

Scaffold protein ILK

ILK_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13418
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ILK
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B7Z1I0, B7Z418, D3DQU0, P57043, Q68DZ3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Domain

ANK repeatRepeat

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Cellular component

Cell junctionCell membraneCell projectionCytoplasmCytoskeletonMembraneNucleus

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