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ASAH2 Antibody

CAT: 0800-F40044-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F40044-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]) .
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q9NR71
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 734-762 from the human protein was used as the immunogen for this ASAH2 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ASAH2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ASAH2 antibody is available for research use only.
Storage Conditions
Aliquot the ASAH2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the ASAH2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
ASAH2 antibody western blot analysis in mouse bladder tissue lysate

UniProtKB · Q9NR71

Neutral ceramidase

ASAH2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NR71
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ASAH2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
N-CDase, NCDase
EC number
3.5.1.-, 3.5.1.23
Processing
—
Secondary accessions
Q3KNU1, Q5SNT7, Q5SZP6, Q5SZP7, Q5T1D5, Q71ME6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisLipid metabolismSphingolipid metabolism

Ligand

CalciumMetal-bindingZinc

Cellular component

Cell membraneGolgi apparatusMembraneMitochondrionSecreted

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Molecular function

Hydrolase

Domain

Signal-anchorTransmembraneTransmembrane helix

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MBS8589590-01ASAH2 Antibody

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