R82913

CAT: 0804-HY-106872Size: 1 EachDry Ice: NoHazardous: No

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Description

R82913 (9-Cl-TIBO) is a potent and high selective inhibitor of HIV-1 reverse transcriptase with antiviral activity on both an RNA template (negative strand synthesis) and a DNA template (positive strand synthesis) . R82913 inhibits the replication of different strains of HIV-I in CEM cells with a median IC50 value of of 0.15 μM[1][2].

CAS Number

126347-69-1

Product Name Alternative

9-Cl-TIBO

UNSPSC

12352005

Target

DNA/RNA Synthesis; HIV; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/r82913.html

Smiles

S=C1N2C3=C(C=C(C=C3N1)Cl)CN([C@H](C2)C)C/C=C(C)\C

Molecular Formula

C16H20ClN3S

Molecular Weight

321.87

References & Citations

[1]White EL, et al. A TIBO derivative, R82913, is a potent inhibitor of HIV-1 reverse transcriptase with heteropolymer templates. Antiviral Res. 1991 Oct;16 (3) :257-66. |[2]Larder BA. 3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother. 1992 Dec;36 (12) :2664-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

R82913

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