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CPrPMEDAP

CAT: 0804-HY-101677-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101677-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin[1][2].
CAS Number
182798-83-0
UNSPSC
12352005
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cprpmedap.html
Purity
99.62
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=NC(NC2CC2)=C3N=CN(CCOCP(O)(O)=O)C3=N1
Molecular Formula
C11H17N6O4P
Molecular Weight
328.26
References & Citations
[1]Compton ML, et al. 9- (2-Phosphonylmethoxyethyl) -N6-cyclopropyl-2,6-diaminopurine (cpr-PMEDAP) as a prodrug of 9- (2-phosphonylmethoxyethyl) guanine (PMEG) . Biochem Pharmacol. 1999;58 (4) :709-714. |[2]Wolfgang GH, et al. GS-9191 is a novel topical prodrug of the nucleotide analog 9- (2-phosphonylmethoxyethyl) guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. Antimicrob Agents Chemother. 2009;53 (7) :2777-2784.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
BA7340-10cPrPMEDAP

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