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Et-29

CAT: 0804-HY-145651-01Size: 5 mgDry Ice: NoHazardous: No
CAT#: HY-145651-01Size: 5 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Et-29 is a potent and selective SIRT5 inhibitor (Ki=40 nM) [1].
CAS Number
[2166487-23-4]
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/et-29.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCC1=CC=CC=C1)N[C@@H](CCCCNC(NCCC(OCC)=O)=S)C(N[C@H](C(NC(C)C)=O)CC2=CNC3=CC=CC=C23)=O
Molecular Formula
C34H46N6O6S
Molecular Weight
666.83
References & Citations
[1]Rajabi N, et al. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew Chem Int Ed Engl. 2017;56 (47) :14836-14841.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT5

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