Et-29

• UNSPSC Description:

  Et-29 is a potent and selective SIRT5 inhibitor (Ki=40 nM)[1].

• Target Antigen:

  Sirtuin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/et-29.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(OCC1=CC=CC=C1)N[C@@H](CCCCNC(NCCC(OCC)=O)=S)C(N[C@H](C(NC(C)C)=O)CC2=CNC3=CC=CC=C23)=O

• Molecular Weight:

  666.83

• References & Citations:

  [1]Rajabi N, et al. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew Chem Int Ed Engl. 2017;56(47):14836-14841.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  2166487-23-4