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XY077

CAT: 0804-HY-163612Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163612Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XY077 (compound 14a) is a RORγ inverse agonist with the IC50 of 0.004 μM. XY077 induces cell apoptosis and shows antiproliferative activity in vivoand in vitro[1].
UNSPSC
12352005
Target
Apoptosis; ROR
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xy077.html
Smiles
O=C(NC1=CC2=C(C=C1)CCCN2S(=O)(CC3=CC=C(C(F)(F)F)C=C3)=O)CC4=CC=C(S(=O)(CC)=O)C=C4
Molecular Formula
C27H27F3N2O5S2
Molecular Weight
580.64
References & Citations
[1]Wu XS, et al. Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer. Acta Pharmacol Sin. Published online May 2, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T209894-01XY077

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