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DDD489

CAT: 0804-HY-168569Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168569Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DDD489 is a potent and selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 values of 0.85 uM.DDD489 shows anti-cryptosporidials activity in vitro and in vivo[1].
CAS Number
3003871-42-6
UNSPSC
12352005
Target
Aminoacyl-tRNA Synthetase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ddd489.html
Smiles
O=C1N(C[C@H]2C[C@@H](C(F)(F)F)CCC2)CC3=NC(N)=NC(C(F)(F)F)=C31
Molecular Formula
C15H16F6N4O
Molecular Weight
382.30
References & Citations
[1]Caldwell N, et al. Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy. Sci Transl Med. 2024;16 (770) :eadm8631.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T201206-01DDD489

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