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2-Aminonicotinaldehyde

CAT: 0804-HY-75813-01Size: 10 gDry Ice: NoHazardous: No
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CAT#:0804-HY-75813-01Size:10 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2-Aminonicotinaldehyde is a key intermediate in organic synthesis. 2-Aminonicotinaldehyde can be used to synthesize 5-HT3 receptor antagonists, AKT inhibitors. 2-Aminonicotinaldehyde can be used in the research of depression and cancer (including hepatocellular carcinoma) [1][2][3].
CAS Number
7521-41-7
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor; Akt; Biochemical Assay Reagents
Type
Biochemical Assay Reagents
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others; PI3K/Akt/mTOR
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-aminonicotinaldehyde.html
Purity
99.99
Solubility
10 mM in DMSO
Smiles
O=CC1=C(N)N=CC=C1
Molecular Formula
C6H6N2O
Molecular Weight
122.13
Precautions
H302, H315, H319, H335
References & Citations
[1]Mahesh R, et al. Design, synthesis and evaluation of antidepressant activity of novel 2-methoxy 1, 8 naphthyridine 3-carboxamides as 5-HT3 receptor antagonists. Chem Biol Drug Des. 2014 May;83 (5) :583-91. |[2]Zhang Z, et al. Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors. J Med Chem. 2022 Feb 24;65 (4) :3249-3265.|[3]Lapierre J M, et al. Discovery of 3- (3- (4- (1-Aminocyclobutyl) phenyl) -5-phenyl-3 H-imidazo [4, 5-b] pyridin-2-yl) pyridin-2-amine (ARQ 092) : An orally bioavailable, selective, and potent allosteric AKT inhibitor[J]. Journal of medicinal chemistry, 2016, 59 (13) : 6455-6469.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Isoform
5-HT3 Receptor

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