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GLPG3312

CAT: 0804-HY-157442-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-157442-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GLPG3312 (Compound 28) is an orally active SIK inhibitor with IC50 values of 2.0 nM, 0.7 nM and 0.6 nM for SIK1, SIK2 and SIK3, respectively. GLPG3312 exhibits anti-inflammatory and immunomodulatory activity in vitro on human primary myeloid cells and in vivo in mouse models. GLPG3312 has good oral bioavailability and can be used for research on inflammatory and immune diseases[1].
CAS Number
2340388-72-7
UNSPSC
12352005
Target
Bcr-Abl; Discoidin Domain Receptor; LIM Kinase (LIMK) ; MAP3K; RIP kinase; Salt-inducible Kinase (SIK) ; Src; TGF-β Receptor
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/glpg3312.html
Purity
98.63
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1CC1)C2=C(OC)C=C(N3C=NC4=CC(C5=CN(C)N=C5)=CC=C34)C=C2OC(F)F
Molecular Formula
C23H21F2N5O3
Molecular Weight
453.44
References & Citations
[1]Temal-Laib T, et al. Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312. J Med Chem. 2024 Jan 11;67 (1) :380-401.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Abl; ACVR2A; Blk; DDR1; Fyn; Hck; Lck; LIMK1; Lyn; RIPK2; SIK1; SIK2; SIK3; Yes

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