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L-NMMA

CAT: 0804-HY-18732-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18732-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-NMMA (Tilarginine; Methylarginine) competitively antagonizes L-arginine, and thus inhibits production of nitric oxide (NO) . L-NMMA is utilized as NO synthase antagonist in experimental settings[1].
CAS Number
17035-90-4
Product Name Alternative
Tilarginine; Methylarginine
UNSPSC
12352211
Hazard Statement
H302, H312, H332
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/l-nmma.html
Purity
99.43
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
OC([C@@H](N)CCCNC(NC)=N)=O
Molecular Formula
C7H16N4O2
Molecular Weight
188.23
Precautions
H302, H312, H332
References & Citations
[1]Frey C, et al., L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. J Biol Chem. 1994 Oct 21;269 (42) :26083-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Citation 01
EMBO Rep. 2025 Oct 20.|Theriogenology. 2025 May 29:245:117517.|Cell Metab. 2025 Jan 7;37 (1) :291-304.e9.|Cell Mol Gastroenterol Hepatol. 2021;11 (3) :683-696.|Cell Mol Gastroenterol Hepatol. 2025 Feb 7:101474.|Eur J Immunol. 2020 Jun;50 (6) :795-808.|FASEB J. 2025 Sep 30;39 (18) :e71057.|Front Cell Dev Biol. 2021 Dec 23;9:741911.|Life Sci. 2025 Jan 24:123415.|Nat Commun. 2021 May 10;12 (1) :2587.|Nat Immunol. 2023 Jan;24 (1) :162-173.